Find The Hunt of Her Life on: Amazon.com Like it on: Facebook.com Join us on: Goodreads.com

The Ruff Report: Dogs and Health


Major breakthrough in cancer treatment
could save the lives of millions of dogs


Researchers believe they may have developed the biological equivalent of a smart bomb that could extend or save the lives of millions of dogs suffering from cancer - a discovery which also could potentially change the way the disease is treated in humans.

Four dogs with advanced, aggressive forms of cancer and on the verge of death are now in remission after taking a drug called nitrosylcobalamin (NO-Cbl), which is able to sneak undetected into cancer cells and destroy them from within.

Story continues below
----------------------------------------------------------------------

A book about a rescue dog
that will touch your heart

THE HUNT OF HER LIFE, is a nonfiction book about Samantha, an unwanted rescue dog who the author adopts at age 2. This beautifully designed full-color deluxe book, by longtime newspaper journalist Joseph A. Reppucci, contains more than 60 vibrant color photos of dogs to help illustrate the compelling and uplifting story of Samantha - a pretty tricolor bird dog who uses her warm personality to win people over and build a new family after being put up for adoption by a hunter because she is gun-shy and afraid to hunt. Learn how she uses her special bonding abilities with people to help her eventually make a transition from the hunting fields to family life. While reading the The Hunt of Her Life, you will travel with Samantha and the author along a trail filled with surprising twists, sudden turns, mystery and even what some call a miracle. And when the journey is finished, you may never look at people and their pets, motherhood - and perhaps even God - in the same way.  The Hunt of Her Life is must reading. It will take you on a captivating journey - a trip like no other - that will touch your heart.

Available at:
Createspace.com (an Amazon.com company)
 
Also find it on: Amazon.com
Join us on:  Goodreads.com

CLICK HERE FOR A FREE LOOK INSIDE THE BOOK 

----------------------------------------------------------------------
 Story continues here
"In all four dogs, there has been a significant reduction in tumor size without any toxic side effects or discomfort," Joseph A. Bauer, a research at the Cleveland Clinic, said in a media release from Science Daily.

Bauer and his research colleagues detailed the extraordinary achievement recently at the 237th national meeting of the American Chemical Society in Salt Lake City.About six million dogs are diagnosed with cancer each year in the United States, according to the National Cancer Institute.

The Morris Animal Foundation of Denver - which has launched a global campaign to raise $30 million money to find a cure for cancer in dogs in the next 10 to 20 years - says one in four dogs die of cancer, and the disease is the number one cause of death in dogs over age 2. Some of the most popular breeds are especially susceptible to cancer. Sixty percent of Golden Retrievers die of the disease.

The first dog treated with nitrosylcobalamin, a 10-year-old Bichon Frise named Oscar, was diagnosed with an extremely aggressive form of cancer called anal sac adenocarcinoma. The dog, bedridden and unresponsive to chemotherapy or radiation, was give a survival time of three months at best. But the dog's cancer receded after he began taking nitrosylcobalamin and he was walking again within two weeks.

Since then, the other dogs treated with the drug are doing well. A 6-year old Golden Retriever named Buddy was unable to walk due to a spinal tumor pinching nerves leading to his right hind leg. After nine months of daily treatment with the drug, Buddy's tumor shrank by 40 percent and he was going on two-mile walks. A 13-year-old female Giant Schnauzer with inoperable thyroid carcinoma also showed tumor reductions of 77 percent in less than 10 weeks.
"This is one of the most rewarding things I've ever done in my life," said Bauer, who owns a 2-year old Beagle. "It gets boring working in the lab, but to see the fruits of your labor in a positive outcome like this and to know you're responsible in some small way, that's pretty cool."

Nitrosylcobalamin targets cancer cells with "biological Trojan horse technology." A Trojan horse is a damage-causing substance hidden in something apparently harmless.
Cells have receptors for vitamin B12 on their outer surface. The receptors serve as docking ports where molecules of the vitamin, essential for cells to divide and multiply, attach and then enter the cell.

Cancer cells grow extra B12 receptors - 100 times more than normal cells - in order to divide at their abnormally rapid pace. Scientists have been trying since the 1950s to exploit that vulnerability and make B12-based drugs that attach to the receptors, sneak into the cell and deliver medication.

Bauer and his colleagues attached molecules of nitric oxide, which kills cancer cells, to vitamin B12. The B12 acts as the Trojan horse, easily slipping into unsuspecting cancer cells. The subsequent release of toxic nitric oxide destroys the cancer cells from within.

"We are one of the few research groups that is offering to treat dogs with cancer that otherwise have no hope," Bauer said. "With no other options available, most people in this situation opt to euthanize so that their pets don't go through the pain of disease and trauma of surgery."

Bauer's goal is to successfully treat 10 dogs with nitrosylcobalamin and slingshot the drug into human use as soon as possible. "[Dogs] breathe the same polluted air and drink the same polluted water that you and I do every day. If you can find an agent to treat cancer that occurs in a dog with success, there is a higher likelihood that you can take that to the human population and have a much higher response rate than with mice."

Bauer says his approach should have a much better chance of getting through the FDA's strict drug approval chain because of the genetic similarity between dogs and humans.

More reports about dogs and cancer:
First-ever canine cancer drug developed
Worldwide effort to cure canine cancer
Making strides in fight against canine cancer

Reports about dogs and flea, tick and insect control:

Pet deaths prompt tougher EPA rules for flea, tick items
Use of flea, tick products a must despite pet deaths

 Stop ticks from dogging - or killing - your pet
Your dog may have you sleeping with thousands of fleas
Get ready for an invasion of dog-biting insects


Reports about dogs and oral health:
The stinking truth behind smelly dog breath
Good oral care can be a lifesaver

Reports about dogs and health:
 A wonder drug guaranteed to help your pet 
Try this fountain of youth for your pet
For pets, your dirty hands are really sickening
This formula is certain to sicken your pet
For your pet, there's a rash of trouble in the air
Only saps let their dogs play fetch with sticks
Your dog is at risk of getting the flu, too
Purebred dogs needlessly suffering, report says
Alarming rise in heartworm a threat to pets
'Speak' to your primary care veterinarian
Dog heart medicine research results promising
Cushing's drug receives FDA approva
lParalyzing diseases of dogs, people linked
More reports about dogs and health

But Bauer stresses he wants to get the nitrosylcobalamin dog treatment approved, too. "I'm committed to the animals, and my goal would be to do a dual clinical trial, Phase One human and Phase One dog," he said.

HOME

THE RUFF REPORT
So easy to read. You choose the topic!
 
Adoption | Food | Health Rescue
Safety and Behavior | Surveys and Studies

 Like MySetterSam on Facebook

Book sets signed by the author available here!

THE HUNT HER LIFE BOOK SERIES: Order your set signed by author Joseph A. Reppucci! The Original will touch your heart and the Sequel will lift your soul. *The Hunt of Her Life signed book series sets are only available to U.S. customers.

Signed Set
*The Hunt of Her Life signed book series sets are only available to U.S. customers.

Holiday discount Book Sets

THE HUNT HER LIFE BOOK SET (unsigned) is offered for a limited time each year at a special holiday discount rate of 25% off. The discount applies to orders received from November 1 through December 24.

Find The Hunt of Her Life on Amazon

Get the Original Book | Get the Sequel Book


The ORIGINAL book is currently listed at 56% OFF on Amazon. Order the Original and Sequel and qualify for free shipping!